Hormonal Regulation of Adipocyte Enzymes
نویسندگان
چکیده
منابع مشابه
Hormonal regulation of hepatic enzymes involved in foreign compound metabolism.
The regulation of hepatic P450s has been the focus of numerous studies because of the importance of these proteins in endocrinology, oncology, and toxicology, as well as drug development. Considerable evidence exists demonstrating that many hepatic P450s are regulated by developmental, sex, or hormonal factors in addition to receptors that interact with foreign chemicals. The focus of work in o...
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The de novo synthesis of long-chain fatty acids, a process that occurs primarily in liver in many species, is high in animals fed on diets with a high content of carbohydrate, and low in starved animals. The activities of the ‘lipogenic’ set of hepatic enzymes follow the same pattern. Two members of this lipogenic set are cytosolic malic enzyme (EC 1.1.1.40), which furnishes most of the NADPH f...
متن کاملHormonal regulation of the differentiation of rat adipocyte precursor cells in primary culture.
A reproducible cell culture system is described that allows the study of adipose conversion in fibroblast-like cells isolated by collagenase digestion of epididymal and perirenal adipose tissue from male rats weighing 70-200 g. Adipose conversion as measured by lipid accumulation and increase in glycerophosphate dehydrogenase (GPDH) activity during differentiation strongly depends on the densit...
متن کاملHormonal regulation of rat foetal lipogenesis in brown-adipocyte primary cultures.
Insulin stimulates lipogenesis by 100% for 5 h by a covalent modulation of acetyl-CoA carboxylase, and by 200% for 24 h by increasing malic enzyme and fatty acid synthase enzymic activities in brown-adipocyte primary cultures. At short times, noradrenaline and isoprenaline decrease lipogenesis. However, phenylephrine and glucagon have no effect. At long times, dexamethasone inhibits lipogenesis...
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In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting conditions or times of elevated energy demands is tightly regulated by neuroendocrine signals, resulting in the activation of lipolytic enzymes. Among the classic regulators of lipolysis, adrenergic stimulation and the insulin-mediated control of lipid mobilisation are the best known. Initially, hormone-sensit...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1973
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)43808-8